Social Stress Drives Sex-Specific Molecular Changes in Female Reward Circuitry
Mouse models and human data reveal that social withdrawal in females involves distinct gene expression patterns in the nucleus accumbens.
Evidence Accumulation Efficiency Predicts Substance Use Better Than Inhibitory Control
A longitudinal study of 1,000 adults suggests decision-making speed, not impulse suppression, is the primary marker for addiction risk.
Lateral Septal PACAP Signaling Modulates Stress and Anxiety in Rodent Models
Localized neuropeptide activity in the lateral septum regulates the neuroendocrine response and shifts behavior toward passive coping.
Baseline Connectivity Predicts Anxiety Improvement in Prefrontal TMS Trial
Pre-treatment neural architecture, rather than post-stimulation connectivity changes, correlates with clinical recovery in patients.
Cannabis Use Blunts Neurocognitive Development in Adolescents
Longitudinal data and hair toxicology link THC exposure to flattened growth in memory and processing speed from ages 9 to 17.
Iron Deficiency Drives Dopaminergic Hypersensitivity in Rodent Restless Legs Model
A study in mice links brain iron deficiency to increased GABA release in the striatal-entopeduncular pathway, mimicking opioid withdrawal.
NMDA Receptor Ablation in Adolescent Mice Triggers Synaptic Rebound
Removing NMDA receptors in the adolescent mouse prefrontal cortex causes an initial spine loss followed by a compensatory synaptic rebound.