SHANK3 Haploinsufficiency in Macaques Reveals Diverse Behavioral, Cognitive Phenotypes
A new macaque model of SHANK3 haploinsufficiency provides insights into Phelan-McDermid syndrome and potential biomarkers.
Secreted GPNMB Drives Alpha-Synuclein Spread in Parkinson's Disease
A new study identifies a microglial-neuronal feedback loop involving GPNMB that exacerbates alpha-synuclein pathology, offering a therapeutic target.
Prefrontal GABAergic Synaptic Plasticity Regulates Cognitive Flexibility
A new study identifies a specific long-range inhibitory synaptic mechanism in the prefrontal cortex crucial for adapting to changing rules.
GABAergic Signaling and SST Interneurons Boost Dendritic Calcium Influx
A new study in mice reveals how specific GABA-A receptors and somatostatin-expressing interneurons can paradoxically enhance neuronal calcium signalin
Arterial Netrin-4 Maintains Adult Sympathetic Neurons in Mice
Intracranial arteries provide a trophic niche that prevents age-related neuronal attrition through a non-inflammatory death pathway.
Hierarchical Retinal Circuits Enhance Low-Contrast Detection in Mice and Humans
A dual-mode synaptic architecture using glutamate clouds and driver cells improves signal sensitivity beyond independent cell channels.
Locomotion Selectively Suppresses Hippocampal Pyramidal Cell Bursting in Mice
All-optical electrophysiology reveals that balanced excitatory and inhibitory inputs modulate gain in CA1 neurons during physical activity.
Nucleus Accumbens Dopamine Regulates Multi-Option Foraging Rates in Mice
A global learning rate in the nucleus accumbens core allows for rapid value integration across six concurrent choices in large arenas.
Visual Cortex Pathways Form Adult-Like Architecture Before Birth
MRI data from 584 neonates show that dorsal and ventral streams develop at different rates during the third trimester.
Norepinephrine Drives Sleep-Dependent Astrocyte Volume Changes in Mouse Cortex
Astrocyte expansion during wakefulness reduces interstitial space and suppresses glymphatic flow via alpha-1 adrenergic signaling.
Lactate Enzyme Overexpression Enhances Remyelination in Animal Models
Restoring glycolysis and lactate production in oligodendrocyte precursors overcomes epigenetic silencing to stimulate myelin repair.
Glioblastoma Cells Hijack Fetal Neural Stem Cell Motors to Spread
Glioblastoma cells use the same dynein-driven and actomyosin-dependent motors as fetal neural stem cells to invade surrounding tissue.