4-Hydroxybenzoic Acid Restores Endogenous Coenzyme Q10 in COQ2-Deficient Patient
A first-in-human trial shows 4-HBA bypasses biosynthetic blocks to improve neurological and renal outcomes in primary CoQ10 deficiency.
Nuclear Membrane Disruption Precedes Cytoplasmic Tau in Anti-IgLON5 Disease
Autopsy and in vitro data show that antibody binding triggers nuclear invaginations and serine 422 phosphorylation before tau aggregates.
Identical EEG Bursts Signal Severe Loss of Brain Network Complexity
A multi-model study identifies identical burst suppression as a default state of simplified excitatory networks in irreversible coma.
FIFA Decision Aid Standardizes Pregnancy Management in Football
A validated five-step framework helps multidisciplinary teams assess risks and support informed participation for pregnant athletes.
Children's Hospitals Delay Effective Surge Strategies Despite Tracking Occupancy
A national study shows a disconnect between capacity metrics and the operational triggers used to mitigate inpatient strain.