Estrogen Protects Female Mice From FGF23-Induced Cardiac Hypertrophy
Estrogen antagonizes fibroblast growth factor 23 signaling in mice, preventing uremic cardiomyopathy and extending survival in females.
Biomarkers Predict Kidney Response to Belimumab in Lupus Nephritis
A Phase 3 post hoc analysis identifies baseline IgA, anti-C1q, and early proteinuria changes as key indicators of treatment success.
MEF2C Network Drives Glomerular Endothelial Proliferation in Diabetic Kidney Disease
Multiomics analysis reveals how SGLT2 inhibitors may stabilize endothelial gene networks to prevent neovascularization and cell death.
Etelcalcetide Reverses Cardiac Dysfunction in Mice with Chronic Hyperphosphatemia
The calcimimetic restores systolic function and reduces fibrosis by directly activating calcium-sensing receptors in the myocardium.
VEGFR1 Blockade Reverses Advanced Diabetic Kidney Damage in Mice
Selective inhibition of VEGFR1 regresses histological lesions and improves survival in murine models of progressive renal failure.
Mild Acute Kidney Injury Minimally Affects Long-Term Kidney Function Decline
A study of 1,603 patients finds that mild to moderate AKI causes a small permanent drop in GFR without accelerating annual decline.
WNK1-mTORC2 Pathway Regulates Murine Potassium Secretion Independently of Aldosterone
Selective disruption of WNK1 or mTORC2 in the distal nephron impairs potassium excretion and causes hyperkalemia in mice.
Biopsy Identifies Non-Diabetic Disease in 59% of Diabetic Patients
A 49,075-patient analysis shows non-diabetic kidney disease reduces the risk of end-stage renal failure by more than half.
Cytotoxic T Cells Expand in Antibody-Mediated Kidney Transplant Rejection
Clonal T cell expansion occurs in antibody-mediated rejection even without histological evidence of T cell-mediated rejection.