Cilta-cel Induces Universal MRD Negativity in High-Risk Smoldering Multiple Myeloma
A phase 2 trial shows 100% of patients achieved deep, sustained responses without prior induction therapy or disease progression.
Large Language Models Reduce Radiology Reporting Time and Transcription Errors
A multicenter study finds LLMs faster than conventional speech recognition but notes inconsistent efficiency and new error types.
AI Model Predicts Axillary Response Using Baseline Mammography
A deep learning tool identifies nodal conversion after neoadjuvant therapy, potentially reducing unnecessary axillary dissections.
Simultaneous Cochlear Implants Improve Long-Term Sound Localization
Adolescents with simultaneous bilateral implants show superior spatial hearing compared to those with a brief sequential delay.
TNM-9 Staging Shows Limited Prognostic Accuracy in Nasopharyngeal Carcinoma
A retrospective study finds the ninth edition TNM system lacks strong survival discrimination when patients receive PET/CT imaging.
Advanced MRI Detects Occult Neuronal Loss in Asymptomatic MCA Occlusion
Soma and neurite density imaging reveals microstructural gray matter damage in stroke-free patients with chronic arterial occlusion.
Isolated MPFL Reconstruction Stabilizes Patella Despite High Femoral Anteversion
Patients with femoral torsion over 30 degrees and minimal maltracking achieved stability without derotational osteotomy in a 2-year study.
Polymeric Clips Match Stapler Safety at Lower Cost in Appendectomy
A retrospective study of 692 patients shows polymeric clips are a cost-effective alternative to staplers for appendiceal stump closure.
Cerebral Oximetry Fails to Improve 2-Year Outcomes in Preterm Infants
A phase 3 trial of 1,601 infants shows no reduction in death or disability when using oximetry to guide early postnatal care.
Danish Registry Data Show Rising ADHD Medication Use and Sex Convergence
Prevalence tripled among girls between 2010 and 2023, though they continue to initiate treatment two years later than boys.
Ubiquinol Slows Motor Decline in Multiple System Atrophy Trial
A Phase 2 trial provides the first placebo-controlled evidence of disease modification by targeting mitochondrial dysfunction in MSA.
Iron Deficiency Drives Dopaminergic Hypersensitivity in Rodent Restless Legs Model
A study in mice links brain iron deficiency to increased GABA release in the striatal-entopeduncular pathway, mimicking opioid withdrawal.