Foamy Microglia and Lipid Metabolism Link to Multiple Sclerosis Lesion Expansion
A distinct microglial subtype and altered lipid pathways drive lesion progression in secondary progressive MS, suggesting new therapeutic avenues.
Higher Rocuronium Dose Linked to Increased First-Attempt Intubation Success in ICU
A secondary analysis suggests that rocuronium doses above 1.2 mg/kg improve intubation success in critically ill ICU patients.
Red Blood Cells Contribute Alpha-Synuclein to Parkinson's Brain Pathology
A new study in human tissues and mouse models identifies erythrocytes as a peripheral source of alpha-synuclein, influencing central nervous system.
Cryoprobe Improves Diagnostic Yield in Transbronchial Lung Biopsy
A multicenter randomized trial finds 1.1-mm cryoprobes provide higher diagnostic yield than 2.0-mm forceps for lung biopsies.
Withholding Response Modulates Perceptual Biases, Alters EEG Signatures
Interrupting the perception-action cycle by omitting a response reconfigures sensory processing and electrophysiological activity.
Idarucizumab Reversal Before Thrombolysis in AIS Patients Shows Comparable Safety
Real-world data suggest intravenous thrombolysis after dabigatran reversal is safe and effective as in non-anticoagulated patients.
Ependymal Cilia Mechanics Control Adult Neural Stem Cell Quiescence
A new study identifies how mechanical forces from ependymal cell cilia regulate neural stem cell activity through specific ion channels.
ABCDEF Bundle Does Not Reduce Delirium, Improves Specific Quality of Life Domain
A randomized trial in Australian ICU patients found no delirium reduction with the ABCDEF bundle, but noted better 90-day 'usual activities' scores.
Multimodal Biomarkers Enhance Parkinsonian Syndrome Diagnosis
Combining dermal alpha-synuclein, 4-repeat tau SAAs, and serum neurofilament light chain improves diagnostic precision for neurodegenerative.
EPAC2 Antagonism Restores Cortical Function, Behavior in Fragile X Mouse Model
Targeting EPAC2 reverses molecular and functional deficits in a preclinical model of Fragile X Syndrome, suggesting a therapeutic avenue.
Protein-Based Model Improves Short-Term Lung Cancer Risk Prediction
A new protein-based model enhances identification of individuals with a smoking history at high short-term risk for lung cancer.
Postpartum Period Linked to Higher Risk of Myasthenia Gravis Exacerbations
A population-based cohort study clarifies the fluctuating risk of myasthenia gravis exacerbations during and after pregnancy.