DSDO Lenses Reduce Axial Elongation More Than DIMS in Myopic Children
A multicenter study of 1,541 participants shows DSDO lenses also suppress physiological eye growth in non-myopic children over 12 months.
Liver Stiffness Better Reflects Cumulative Hepatic Injury Than Iron Concentration in Thalassemia
Elastography identifies advanced fibrosis in transfusion-dependent patients even when iron levels are well-controlled by chelation therapy.
Low-Burden COPD Exacerbations Predict Future Respiratory Events
Even home-managed symptoms or a single moderate event correlate with structural lung damage and increased risk of future crises.
Neural Responses to Reward Uncertainty Linked to Adolescent Anxiety and Anhedonia
Striatal and default network activity during uncertain reward tasks correlates with symptom severity in medication-free adolescents.
Baricitinib Noninferior to Etanercept for Reducing Ultrasound-Assessed Synovitis
A phase IV trial shows baricitinib, with or without methotrexate, matches etanercept in objective measures of joint inflammation.
Quantiferon-CMV Guided Prophylaxis Fails to Lower Infection in Seropositive Kidney Recipients
Early post-transplant immune monitoring did not reduce infection rates compared to standard preemptive therapy in low-risk patients.
Kratom Leaf Extract Alleviates Stress-Induced Bladder Dysfunction in Male Mice
Oral mitragynine reduces bladder pain, mast cell infiltration, and muscarinic hyperreactivity in a murine model of chronic stress.
Oral Dysbiosis Linked to Systemic Inflammation and Autism Symptoms
Review identifies enrichment of Porphyromonas and Tannerella as potential drivers of neurodevelopmental patterns via the oral-brain axis.
Guillain-Barré Syndrome Incidence Declined 9% in Japan During the Pandemic
A nationwide survey reveals a shift toward demyelinating subtypes and older patients as conventional infectious triggers decreased.
Telehealth and In-Person Lung Cancer Screening Consultations Show Equivalent Quality
A study of Veterans Affairs patients found no significant difference in shared decision-making quality or scan adherence between modalities.
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[89Zr]girentuximab PET Identifies Any Renal Malignancy with 98% Positive Predictive Value
A secondary analysis of the ZIRCON trial indicates the CAIX-targeted tracer detects non-clear cell subtypes with high clinical accuracy.
Remote Ischaemic Preconditioning Fails to Prevent Postoperative Myocardial Injury
A randomized trial of two-session preconditioning in abdominal surgery shows no reduction in injury and a paradoxical troponin increase.