Cognitive Reserve Delays Symptom Onset in Dominantly Inherited Alzheimer Disease
Higher cognitive reserve is associated with a fourfold increase in the odds of remaining asymptomatic despite genetic risk factors.
Iodine Antiseptics Safe for Patients With Documented Iodine Allergy Labels
A prospective study of 1,211 joint replacements shows no allergic reactions to povidone-iodine protocols in patients with allergy labels.
Medically Assisted Reproduction Shows No Independent Link to Perinatal Distress
A prospective cohort study of 9,289 women found that baseline characteristics, not conception mode, drive mental health outcomes.
Prefrontal Hypoactivation and Time Distortion Linked to Adolescent Self-Injury
Adolescents who self-harm show reduced left dorsolateral prefrontal cortex activity and a distinct inability to accurately estimate time.
Heart Failure Palliative Research Shifts Toward Frailty and Prognostic Tools
A 25-year bibliometric analysis of 1,619 studies tracks the evolution from basic survival data to complex care coordination.
Reduced-Dose JAK Inhibitors Maintain Persistence in Low-Risk Rheumatoid Arthritis
A Japanese registry study of 1,135 patients finds reduced dosing effective for those with preserved renal function and few risk factors.
AI Detects Occult Pancreatic Cancer 15 Months Before Radiologists on CT
A validated radiomics model identifies subvisual signatures of pancreatic ductal adenocarcinoma with 73% sensitivity at a 475-day lead time.
IVUS Guidance Reduces Target Vessel Failure in Complex Bifurcation PCI
A randomized trial shows IVUS-guided optimization more than halves the 1-year risk of failure in complex double kissing crush procedures.
Early Postnatal Oxytocin Restores Hippocampal Plasticity in Fragile X Mice
Intranasal administration during a specific developmental window permanently corrects episodic memory and synaptic deficits in Fmr1-knockout mice.
Nasoalveolar Molding Limits Early Lip Revisions in Cleft Patients Through Maturity
A 20-year follow-up shows only 3.7% of patients required lip revision before reaching skeletal maturity after nasoalveolar molding.
GLP-1 Receptor Agonists Reduce Psoriasis Severity in Patients With Obesity
A National Psoriasis Foundation primer details how incretin therapies lower skin scores and systemic inflammatory markers.
Lung Ultrasound Reaches 94% Sensitivity for Pediatric Pneumonia Diagnosis
Meta-analyses indicate point-of-care ultrasound offers up to 96% specificity while eliminating radiation exposure in children.