Elevated hsCRP and Oxidative Stress Predict Musculoskeletal Injury Risk
A prospective study of US Army trainees finds systemic biomarkers rise in the week preceding clinical diagnosis of musculoskeletal injury.
Plasmodium knowlesi Adapts In Vitro to Infect Duffy-Negative Erythrocytes
A chimeric gene allows the zoonotic parasite to bypass the Duffy-antigen receptor, suggesting potential for wider geographic spread.
MEF2C Network Drives Glomerular Endothelial Proliferation in Diabetic Kidney Disease
Multiomics analysis reveals how SGLT2 inhibitors may stabilize endothelial gene networks to prevent neovascularization and cell death.
Simple Thoracostomy Shows Higher Success Rate Than Needle Decompression in Cadavers
A crossover study using fresh human cadavers found that simple thoracostomy achieved faster and more complete pleural decompression.
Multi-Echo T2* MRI Identifies Neonatal Hemochromatosis via Extrahepatic Iron Patterns
Pancreatic and thyroid siderosis on MRI distinguishes neonatal hemochromatosis from other liver failure causes with 92.3% accuracy.
Mim8 Prophylaxis Reduces Bleeding in Hemophilia A with or without Inhibitors
Phase 3 data show weekly or monthly subcutaneous Mim8 significantly lowers bleeding rates compared to on-demand and prior factor therapy.
Brain Fluoxetine Levels Fail to Predict Clinical Response in Youth
Neurometabolic markers of neuronal integrity, not drug concentrations, correlate with symptom improvement in adolescent depression.
Healthy Lifestyle Lowers Diabetic Retinopathy Risk Despite Genetic Predisposition
A polygenic risk score analysis shows that favorable behaviors reduce retinopathy rates by 44 percent in high-risk patients.
Renal Macrophage Shifts Drive Glomerulosclerosis in Lupus Nephritis Progression
Spatial transcriptomics reveals that disease-specific macrophages interact with parietal epithelial cells to promote renal scarring.
Intranasal Ketamine Reduces Existential Distress in Advanced Cancer Patients
Secondary analysis shows three doses of intranasal ketamine improve death-related anxiety and existential well-being in palliative care.
Clinical Models Improve Pediatric Referral Accuracy in Southeast Asia
New triage tools utilizing pulse oximetry and sTREM1 show higher sensitivity for severe febrile illness than current WHO standards.
Mandibular Septum Mapping Identifies Safe Zones for Lower Face Surgery
Cadaveric dissections reveal the mandibular septum's continuity with the platysma-mandibular ligament and its distance from motor nerves.