Digitalis Reduces Worsening Heart Failure Events in Large Meta-Analysis
A study of 9,013 patients shows digitalis glycosides lower the risk of worsening heart failure events without affecting mortality.
Ruxolitinib Resolves Severe Diarrhea Following BCMA-Targeted CAR T-Cell Therapy
A case series suggests JAK inhibition may mitigate the high mortality associated with immune-mediated enterocolitis in multiple myeloma.
Arterial Netrin-4 Maintains Adult Sympathetic Neurons in Mice
Intracranial arteries provide a trophic niche that prevents age-related neuronal attrition through a non-inflammatory death pathway.
Hierarchical Retinal Circuits Enhance Low-Contrast Detection in Mice and Humans
A dual-mode synaptic architecture using glutamate clouds and driver cells improves signal sensitivity beyond independent cell channels.
PRECISE MRI Scoring Predicts Histological Progression in Prostate Cancer Surveillance
A multicenter study of 1,667 patients validates the PRECISE system for identifying disease progression and reducing unnecessary biopsies.
Long-Read Sequencing Resolves Atypical Facioscapulohumeral Dystrophy Loci
High-resolution sequencing identifies complex structural variants in the 1% to 2% of patients who lack standard genetic markers.
NXT007 Reaches Nonhemophilic Factor VIII Levels in Severe Hemophilia A
A phase 1/2 trial shows monthly subcutaneous NXT007 achieves factor activity above 40 IU/dL and eliminates bleeds at higher doses.
Carotid Doppler Parameters Predict Return of Spontaneous Circulation During CPR
Waveform-derived metrics like velocity time integral show high predictive value for resuscitation success in emergency department patients.
Locomotion Selectively Suppresses Hippocampal Pyramidal Cell Bursting in Mice
All-optical electrophysiology reveals that balanced excitatory and inhibitory inputs modulate gain in CA1 neurons during physical activity.
Photon-Counting CT Improves Pulmonary Artery Visibility at Lower Radiation Doses
Ultra-high-resolution imaging increases diagnostic confidence and vascular attenuation compared to standard energy-integrating detectors.
Selective HDAC6 Inhibition Restores Axonal Transport in Preclinical ALS Models
A brain-penetrant small molecule improves motor function and reduces TDP-43 pathology in animal and human cellular models of neurodegeneration.
Amygdala Damage Does Not Impair Intrinsic Motivation to Empathize
Patients with focal amygdala lesions maintain a normal drive to engage in empathic encounters despite deficits in emotional recognition.