FDA-Approved Therapies and Multidisciplinary Care Extend Survival in ALS
New clinical data highlight the role of genetic testing and targeted therapies in managing progressive motor neuron degeneration.
Gene Expression Score Predicts Survival in Myelofibrosis
A 24-gene signature derived from stem cells identifies high-risk patients missed by current clinical and mutation-based scoring systems.
JMJD1C Deficiency Drives Pathogenic Antibody Production in Heparin-Induced Thrombocytopenia
Loss of the histone demethylase JMJD1C triggers B-cell hyperactivation and the production of platelet-activating antibodies.
FGF14 Repeat Expansions Identified in Patients with Parkinson's Disease
Long-read sequencing reveals that a genetic variant linked to ataxia also occurs in patients meeting clinical criteria for Parkinson's.
Acupuncture and Herbal Formula Improve Visual Acuity in Optic Atrophy
Combining acupuncture with Jieyu Huoxue Formula reduces blood viscosity and increases peak systolic velocity to protect the optic nerve.
Extracorporeal Limb Perfusion Does Not Exacerbate Bleeding in Porcine Trauma Model
A study of Lower Extremity Extracorporeal Distal Revascularization shows stable clot integrity despite uncontrolled vascular injuries.
Tirzepatide Reduces Major Kidney Events More Than Dulaglutide
In patients with type 2 diabetes and cardiovascular disease, tirzepatide lowered the risk of renal outcomes by 23% over four years.
Commercial AI for Lung Cancer Screening Lacks Full Guideline Alignment
An analysis of 16 CE-marked products reveals gaps in managing cystic lesions and a lack of prospective evidence for patient outcomes.
Cerebrotendinous Xanthomatosis Drives Recurrent Stroke After PFO Closure
A 23-year-old's recurrent M1 occlusion reveals how metabolic drivers of premature atherosclerosis can mimic or coexist with structural defects.
Intra-Arterial Alteplase Improves Recovery After Successful Thrombectomy
Adjunctive thrombolysis increased 90-day functional independence by 15% but was associated with a nearly 6% increase in mortality.
Pediatric Fibula Harvest Carries High Risk of Ankle Valgus and Nerve Palsy
A 27-year review identifies the Age-Residual Fibula Index as a key predictor for donor-site morbidity in skeletally immature patients.
Deucravacitinib Modulates Over 2,500 Genes in Systemic Lupus Erythematosus
Transcriptomic analysis shows TYK2 inhibition reverses myeloid dysregulation and increases regulatory T-cell populations in patients with lupus.