Pimicotinib Yields 54% Response in Tenosynovial Giant Cell Tumors
The selective inhibitor pimicotinib demonstrates high efficacy for unresectable joint tumors while avoiding severe hepatotoxicity.
Zorevunersen Cuts Convulsive Seizures in Children With Dravet Syndrome
The investigational antisense therapy reduced convulsive-seizure frequency by up to 90.91% and improved adaptive behavior over 36 months.
Seven Hours of Sleep Maximizes Depression Risk Reduction in Older Adults
A national cross-sectional study reveals a non-linear relationship where the mental health benefits of sleep attenuate after seven hours.
ADHD Linked to Attenuated Rightward Structural Asymmetry in Children
MRI data reveal that reduced right-hemisphere dominance in frontal and striatal regions correlates with impaired attention and timing.
Finerenone Reduces Albuminuria in Type 1 Diabetes and CKD
A phase 3 trial shows the mineralocorticoid receptor antagonist finerenone safely lowers albuminuria in adults with type 1 diabetes.
Baxdrostat Reduces 24-Hour Blood Pressure in Resistant Hypertension
A phase 3 trial shows the selective aldosterone synthase inhibitor baxdrostat reduces systolic blood pressure by 14 mm Hg versus placebo.
Neoadjuvant GOLP Doubles Event-Free Survival in Cholangiocarcinoma
Administering the GOLP regimen before surgery extends median event-free survival to 18 months in high-risk intrahepatic cholangiocarcinoma.
LGBTQ+ EMS Clinicians Balance Professional Identity and Disclosure
A qualitative analysis reveals how LGBTQ+ prehospital clinicians navigate workplace disclosure while prioritizing their clinical skills.
Sleep Under 6.7 Hours Linked to Depression in Opioid Users
A U-shaped dose-response curve reveals that insufficient sleep increases depression risk by 60% among adults taking prescription opioids.
Lab and Point-of-Care Electrolyte Tests Diverge in 10% of ICU Cases
A prospective study reveals that central lab and point-of-care sodium and potassium measurements are not interchangeable in critical care.
Digital Dyadic Interventions Improve Cognition and Reduce Caregiver Burden
A review of 38 studies finds digital tools like mobile apps and remote platforms enhance patient cognition and ease caregiver burden.
Real-World CBT Improves Distress but Not Pain in Functional Neurological Disorder
Routine clinical data from 234 adults shows cognitive behavioral therapy significantly reduces psychological distress but not physical pain.