VWF Deficiency Drives Angiodysplasia via Angiopoietin-2 Dysregulation
New research identifies a molecular pathway linking von Willebrand factor deficiency to gut angiodysplasia, suggesting a targeted therapeutic…
IV Iron Linked to Improved Survival, Anemia Recovery in Acute Infection
A retrospective cohort study suggests intravenous iron administration during acute infection does not worsen outcomes and may offer benefits.
French NOMADMUS Cohort Details AQP4+NMOSD, MOGAD Trends
A nationwide registry in France provides real-world data on diagnostic and therapeutic shifts, and disease activity in AQP4+NMOSD and MOGAD.
CT-Detected White Matter Disease Signals Higher Stroke/Dementia Risk Than MRI-Only Findings
A large cohort study reveals distinct prognostic implications for covert cerebrovascular disease based on imaging modality.
Multiomic Analysis Reveals CTCL Progression Mechanisms, Identifies Therapeutic Targets
A comprehensive multiomic study uncovers specific molecular alterations driving cutaneous T-cell lymphoma progression and therapy resistance.
Smoking Cessation Reduces Dementia Risk, But Weight Gain May Attenuate Benefit
A large prospective cohort study indicates quitting smoking lowers long-term dementia risk, though substantial post-cessation weight gain may…
True Refractoriness to Caplacizumab in iTTP Is Rare
A multicenter study found that delayed platelet recovery in iTTP patients on caplacizumab is usually due to confounding factors, not true…
Itraconazole Inhibits OXPHOS in AML, Targets Therapy-Resistant Leukemic Stem Cells
A drug-repurposing screen identifies the antifungal itraconazole as an oxidative phosphorylation inhibitor effective against AML leukemic stem cells.
ERV Reactivation Drives C4b-Mediated Synaptic Pruning in Autism Models
In mouse models, endogenous retrovirus reactivation leads to C4b upregulation and excessive microglial pruning, contributing to autistic-like…
Homozygous LGI1 Variant Linked to Severe Developmental and Epileptic Encephalopathy
A case report details a homozygous LGI1 gene variant causing drug-resistant epilepsy and profound developmental delay, contrasting with typical.
Orca-T Immunotherapy Enriches Regulatory-Like T-Cells Early Post-Transplant
A specific T-cell subset, CD4+CD25-FOXP3+Helios+ T conventional cells, is enriched early after Orca-T and correlates with later immune activation.
Blood Test Monitors Brain Gene Expression in Nonhuman Primates
A new method uses engineered reporters to noninvasively track transgene activity in primate brains via a simple blood draw.