One in Three ICH Patients on Antithrombotics Lack Clinical Indication
A retrospective study finds 30.4% of patients with intracranial hemorrhage were taking unindicated anticoagulants or antiplatelets.
Injectable Antipsychotics Reduce Hospitalization and Relapse in Bipolar Disorder
A mirror-image study shows paliperidone and aripiprazole long-acting formulations significantly lower psychiatric service use and relapse.
Daily Resistance Training and Verticalization Safe During ECMO Support
A pilot study shows that structured mobility and resistance exercises correlate with improved functional performance in critically ill adults.
Stroke Etiology Does Not Alter Bridging Thrombolysis Efficacy
A meta-analysis of six trials finds no interaction between stroke cause and the benefit of thrombolysis before mechanical thrombectomy.
Specific Combination Therapies Reduce Hospitalization Risk After Lithium Failure
A large cohort study identifies clozapine and long-acting injectable combinations as effective alternatives for maintenance treatment.
Plasma Heme Assay Predicts Mortality Risk in Sickle Cell Disease
Direct quantification of heme species identifies patients with severe hemolysis and exhausted scavenging capacity better than indirect markers.
Network Connectivity Drives Individual Variation in Emotional Memory
Large-scale fMRI study finds distributed neural networks, not isolated amygdala activity, predict how emotional arousal enhances recall.
Adolescent Opioid Harms Double Despite Reduced Emergency Department Prescribing
A decade-long study of 1.2 million visits shows that cutting pediatric opioid prescriptions did not prevent a rise in clinical harms.
Pyramidal Cell Hypofunction Predicts Psychosis Conversion in High Risk Patients
Biophysical modeling of auditory biomarkers suggests that excitatory deficits, not interneuron dysfunction, drive the transition to psychosis.
Periarticular Injection Reduces Opioid Use After Knee Infection Surgery
A retrospective study of 309 patients shows local anesthetic infiltration lowers pain scores without increasing 12-month reinfection risk.
Structured Exercise and Resistance Training Safe During ECMO Support
A pilot study of 20 patients shows that intensive twice-daily rehabilitation correlates with improved functional performance and survival.
Adolescents at Risk for Bipolar Disorder Show High Self-Harm and Comorbidity Rates
A 12-month study of UK youth finds that those screening positive for bipolar risk receive alternative diagnoses and intensive services.