British Journal of Anaesthesia
12 articles tagged "British Journal of Anaesthesia"
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Propofol Reduces Long-Term Water Contamination Compared to Sevoflurane
A modeling study finds sevoflurane leads to irreversible accumulation of trifluoroacetic acid while propofol residues remain biodegradable.
Low Cardiac Index During Hypotension Increases Acute Kidney Injury Risk
A study of 1,272 cardiac surgery patients finds that hypotension only correlates with renal injury when cardiac index falls below 2.
C1q-Mediated Synaptic Pruning Drives Postoperative Cognitive Decline in Murine Models
Surgical trauma triggers NF-κB signaling and C1q-dependent microglial phagocytosis of hippocampal synapses, leading to memory impairment.
Sleep Loss Delays Rat Surgical Recovery via Epigenetic Opioid Receptor Suppression
REM sleep disturbance downregulates the TET1 enzyme, reducing mu-opioid receptor expression in the spinal cord and dorsal root ganglion.
Low Cerebral Perfusion Pressure Increases Delirium Risk After Cardiac Surgery
A cohort study of 1,759 patients suggests that maintaining the balance between arterial and venous pressures may prevent delirium.
Microglial Activation Disrupts Hippocampal Memory Consolidation in Aged Mice After Surgery
Surgical stress triggers neuroinflammation that inhibits CA3 to CA1 signaling, reducing sharp-wave ripples essential for memory.
Videolaryngoscopy Increases First-Attempt Success for Double-Lumen Tube Intubation
A multicenter trial of 916 patients shows digital visualization improves glottic view and reduces esophageal intubation rates.
Airway Ultrasound Training Lacks Global Standardization Despite Clinical Utility
A scoping review of 11 training programs reveals inconsistent curricula and significant barriers to formal anesthesia education.
Remimazolam Impairs Thalamic Auditory Gating During Recovery in Mouse Models
Dysfunction in the thalamic reticular nucleus leads to sensory hypersensitivity and rebound neuronal enhancement following anesthesia.
Remote Ischaemic Preconditioning Fails to Prevent Postoperative Myocardial Injury
A randomized trial of two-session preconditioning in abdominal surgery shows no reduction in injury and a paradoxical troponin increase.
Anesthesia Trials Lack Precise Definitions for Perioperative Disruptions
A review of 139 trials finds 60% fail to report how they handle events like surgery cancellations or treatment switching.
Hypothalamic Astrocytes Drive Dexmedetomidine Sedation via Calcium Signaling in Mice
Researchers identified a specific astrocytic pathway that modulates inhibitory GABA currents to facilitate pharmacological sedation.