SF3B1 Mutations Increase DCAF16 Expression to Create Targeted Therapeutic Vulnerability
Splicing alterations in noncoding mRNA regions drive gain-of-function protein expression, allowing selective degradation of cancer targets.
Common Genetic Variants Linked to Acute Myeloid Leukemia Risk and Survival
A meta-analysis identifies four new germline loci associated with specific cytogenetic subtypes and clinical outcomes in myeloid malignancy.
CFLIP Inhibition Triggers Extrinsic Apoptosis in ABC Subtype Lymphoma Models
Murine and human cell studies identify cFLIP as a requirement for B-cell lymphomagenesis and a potential target in refractory disease.
Donor-Derived Anti-CD33 CAR T-Cells Show Safety in Relapsed AML Post-Transplant
A phase 1/2 trial of VCAR33 demonstrates manageable toxicity and preliminary activity in patients with relapsed or MRD-positive disease.
HLA Class III Variant rs915654 Predicts Survival in Haploidentical Transplantation
A specific genetic marker within the HLA class III region improves risk stratification for relapse and mortality in stem cell recipients.
Interferon-Gamma Drives Chronic Bone Marrow Damage After Doxorubicin in Mice
Targeting T-cell-driven inflammation may prevent long-term skeletal and hematopoietic defects observed in leukemia survivors.
Cryo-EM Maps Molecular Shift Producing Thrombin in Coagulation Cascade
Researchers identify a 20-angstrom reorientation required for the final proteolytic cleavage of prothrombin into active thrombin.