DHODH Inhibition Targets Pyrimidine Synthesis in Chemo-Resistant B-ALL
A new study identifies dihydroorotate dehydrogenase (DHODH) as a metabolic vulnerability in B-ALL cells with active signaling.
Platelet mTOR Pathway Drives Neuropathogenesis in Cerebral Malaria
A new study identifies the mechanistic target of rapamycin (mTOR) in platelets as a key mediator of brain injury in experimental cerebral malaria.
CircPCMTD1 Peptide Regulates DNA Damage Response in BCR/ABL1-Positive Leukemias
A newly characterized circular RNA and its peptide product modulate genotoxic stress tolerance, offering a potential therapeutic target.
PSMD1 Inhibition via LNPs Reduces Myeloma Growth, Overcomes Resistance
Targeting the proteasome subunit PSMD1 with siRNA delivered by lipid nanoparticles shows efficacy in multiple myeloma models.
Ibrutinib Response in WM Linked to Clonal Evolution, T-Cell Dynamics
A single-cell analysis reveals distinct tumor evolution patterns and immune cell changes predicting ibrutinib outcomes in Waldenström macroglobulinemi
IBD Inflammation Augments CHIP Risk, APE1/Ref-1 Identified as Therapeutic Target
A new study links inflammatory bowel disease to increased clonal hematopoiesis of indeterminate potential, identifying a specific molecular pathway.
NPM1-Mutated AML: Nuclear Condensates Drive HOX/MEIS1 Expression, Inform Menin Inhibitor Action
New research clarifies how mutant NPM1 forms nuclear condensates, sustaining oncogenic transcription and explaining menin inhibitor efficacy.
Daratumumab-VCd Improves Survival, Organ Function in AL Amyloidosis
Final ANDROMEDA analysis confirms sustained benefits of D-VCd for newly diagnosed light-chain amyloidosis, including overall survival.
Tfr2 Essential for Acute Hepcidin Induction in Tfr1-Deficient Mouse Hepatocytes
A murine study reveals that transferrin receptor 2 and HFE must cooperate to trigger hepcidin during rapid iron fluctuations.
Circulating Tumor DNA Predicts Progression-Free Survival in Hodgkin Lymphoma
A validated sequencing assay identifies patients at high risk for relapse after two cycles of chemotherapy in the GHSG HD21 trial.
Gene Expression Score Predicts Survival in Myelofibrosis
A 24-gene signature derived from stem cells identifies high-risk patients missed by current clinical and mutation-based scoring systems.
JMJD1C Deficiency Drives Pathogenic Antibody Production in Heparin-Induced Thrombocytopenia
Loss of the histone demethylase JMJD1C triggers B-cell hyperactivation and the production of platelet-activating antibodies.