Annals of the Rheumatic Diseases
9 articles tagged "Annals of the Rheumatic Diseases"
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Expert Consensus Standardizes SSA/Ro Autoantibody Nomenclature
A Delphi process involving 17 international experts recommends specific terms for anti-TROVE2/Ro60 and anti-TRIM21/Ro52 autoantibodies.
CCL19 Tracks IgG4-Related Disease Activity, Supplements IgG4 Levels
A new study identifies C-C motif chemokine ligand 19 as a dynamic serum biomarker for monitoring IgG4-RD treatment response and relapse.
PsA Improvement Thresholds Vary by Baseline Disease Activity, Not Prior TNFi Exposure
Minimal clinically important improvement (MCII) thresholds in psoriatic arthritis depend on baseline disease severity, guiding personalized treatment.
Deucravacitinib Modulates Over 2,500 Genes in Systemic Lupus Erythematosus
Transcriptomic analysis shows TYK2 inhibition reverses myeloid dysregulation and increases regulatory T-cell populations in patients with lupus.
Renal Macrophage Shifts Drive Glomerulosclerosis in Lupus Nephritis Progression
Spatial transcriptomics reveals that disease-specific macrophages interact with parietal epithelial cells to promote renal scarring.
Reduced-Dose JAK Inhibitors Maintain Persistence in Low-Risk Rheumatoid Arthritis
A Japanese registry study of 1,135 patients finds reduced dosing effective for those with preserved renal function and few risk factors.
Baricitinib Noninferior to Etanercept for Reducing Ultrasound-Assessed Synovitis
A phase IV trial shows baricitinib, with or without methotrexate, matches etanercept in objective measures of joint inflammation.
C5a Receptor Antagonism Shows Steroid-Sparing Effect in Vasculitis
While C5a inhibition demonstrates clinical benefit in vasculitis, trials in rheumatoid arthritis show more limited therapeutic efficacy.
Silent Urate Deposits Found in 39% of Asymptomatic Hyperuricemia Patients
Standardized ultrasound reveals subclinical crystal deposition is linked to early joint erosion and synovial inflammation before the first gout flare.