The Briefing
Continuous newsroom coverage of clinically relevant evidence — newest first.
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Mental Health Gains Tied to Cessation, Not E-Cigarette Switching
A large study links complete cessation to better mental health over time, a benefit not seen in those who switch to e-cigarettes.
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Serum Neurofilament Light Chain Identifies Subclinical Axonal Injury in SMA Neonates
Elevated serum neurofilament light chain levels predict two-year motor outcomes and reveal active denervation before clinical symptoms appear.
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CTA Plaque-RADS Predicts Ipsilateral Recurrence in Embolic Stroke
A standardized scoring system for nonstenotic carotid plaques identifies a distinct ESUS subgroup with a threefold higher risk of recurrence.
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US Adult Obesity Projected to Reach 47 Percent by 2035
An analysis of over 11 million adults reveals severe racial and geographic disparities as obesity rates continue to climb nationwide.
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Maternal Depressive Symptoms Nearly Double Preeclampsia Risk
A meta-analysis of over 44,000 pregnancies shows early depressive symptoms significantly elevate the risk of hypertensive complications.
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Hippocampus-Thalamus Circuit Drives Contextual Hyperactivity in PTSD Mouse Model
A specific glutamatergic pathway may be a therapeutic target for context-dependent arousal symptoms.
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Consensus Algorithm Standardizes Rural Air Medical Transport Triage
A multidisciplinary panel used a Delphi survey to identify 18 patient factors and 6 interventions that warrant helicopter transport.
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Oral Celecoxib and Ciprofloxacin Slow Functional Decline in ALS
A phase 2b trial shows the fixed-dose combination is safe and reduces the risk of severe complications over 18 months in early-stage ALS.
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Nicotine Rewires Habenular Circuits in Mice, Altering Food Motivation
Chronic nicotine exposure in mice disrupts top-down control of the LDT-VTA cholinergic axis, driving exaggerated food-seeking behavior.
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Vitamin C Reverses Depression-Like Behavior in Female Mice via D2 Receptors
A single dose of ascorbic acid restored dopamine D2 receptor signaling in the prefrontal cortex, rapidly alleviating depression in mice.
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Inhibiting RhoA in Rat Prefrontal Cortex Reduces Morphine Dependence
Blocking the RhoA pathway in rats reduces opioid-induced neuroplasticity and limits glutamate spillover, offering a specific addiction target.
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Epigenetic Target HDAC5 Reduces Environment-Triggered Cocaine Seeking in Rats
In a rat model, overexpressing the enzyme HDAC5 in the prelimbic cortex shifted synaptic balance to suppress context-driven cocaine seeking.
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Cognitive Status Remains Key Predictor of Dementia Risk Alongside p-tau181
ARIC data show that while p-tau181 is prognostic, the absolute risk of dementia remains low in cognitively unimpaired individuals.
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Young Children Require Higher Benzodiazepine Doses for PICU Ventilation
A retrospective cohort study reveals that children under five receive significantly higher weight-adjusted doses of midazolam and lorazepam.
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Social Anxiety Affects Nearly Half of College Students
An analysis of 5,996 students reveals a 47.9% incidence of social anxiety, with gender, grade, and physical activity as top predictors.
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Caffeinated Coffee and Tea Lower Dementia Risk; Decaf Shows No Benefit
A 43-year prospective study of 131,821 adults reveals that 2 to 3 cups of caffeinated coffee daily significantly reduces incident dementia.
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Cross-Ancestry Analysis Identifies Shared Genetic Risk for Major Psychiatric Disorders
Researchers identified 403 genetic loci and specific cellular pathways common to schizophrenia, bipolar disorder, and depression.
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Glioblastoma Cells Hijack Fetal Neural Stem Cell Motors to Spread
Glioblastoma cells use the same dynein-driven and actomyosin-dependent motors as fetal neural stem cells to invade surrounding tissue.
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Apps for Alcohol Use Do Not Improve Mood Beyond Standard Care
In a randomized trial, digital tools added to standard care did not further reduce depression or anxiety in adults with alcohol dependence.
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Intracortical Implant Enables Paralyzed Patients to Type 22 Words Per Minute
By decoding attempted finger movements, a neuroprosthesis allows patients with tetraplegia to type on a virtual QWERTY keyboard.
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Bedside Score Predicts Successful Dialysis Discontinuation in ICU Patients
The UNDERSCORE tool uses six routine clinical variables to help physicians determine if critically ill patients can safely stay off dialysis.
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East Asian Registry Details Distinct Demyelinating Disease Profile
A Korean registry reveals that antibody-mediated conditions account for nearly half of central nervous system demyelinating cases.
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Algorithm Predicts Mortality in Carbapenem-Resistant ICU Infections
A LightGBM model using routine clinical data accurately predicted 15-day mortality, highlighting coagulopathy and time to antibiotics.
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Opioid Medications Halve Mortality but Reach Only a Quarter of Patients
A clinical review details how optimizing methadone, buprenorphine, and naloxone can close the treatment gap and reduce all-cause mortality.