The Briefing
Continuous newsroom coverage of clinically relevant evidence — newest first.
Earlier
24 stories-
Self-Mixed Morphine Gel Reduces Pain and Systemic Opioid Use in Cancer
A 0.125% topical morphine gel mixed by patients reduced pain scores by 61.8% and significantly lowered daily oral morphine requirements.
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Bitemporal ECT and rTMS Plus SSRIs Reduce Suicidal Ideation
A network meta-analysis of 58 trials finds nonconvulsive brain stimulation alone is ineffective for suicidal ideation without medication.
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Community CPR Training Increases Bystander Response but Not Defibrillator Use
A study of 6,280 cardiac arrests shows high training rates boost chest compressions while device use remains stagnant at less than 1%.
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Buprenorphine Initiation Succeeds in 71% of Opioid-Tolerant Cancer Patients
A retrospective study shows transdermal and buccal buprenorphine reduce pain scores with low rates of precipitated withdrawal.
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Cilta-cel Induces Universal MRD Negativity in High-Risk Smoldering Multiple Myeloma
A phase 2 trial shows 100% of patients achieved deep, sustained responses without prior induction therapy or disease progression.
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Large Language Models Reduce Radiology Reporting Time and Transcription Errors
A multicenter study finds LLMs faster than conventional speech recognition but notes inconsistent efficiency and new error types.
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AI Model Predicts Axillary Response Using Baseline Mammography
A deep learning tool identifies nodal conversion after neoadjuvant therapy, potentially reducing unnecessary axillary dissections.
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Simultaneous Cochlear Implants Improve Long-Term Sound Localization
Adolescents with simultaneous bilateral implants show superior spatial hearing compared to those with a brief sequential delay.
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TNM-9 Staging Shows Limited Prognostic Accuracy in Nasopharyngeal Carcinoma
A retrospective study finds the ninth edition TNM system lacks strong survival discrimination when patients receive PET/CT imaging.
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Advanced MRI Detects Occult Neuronal Loss in Asymptomatic MCA Occlusion
Soma and neurite density imaging reveals microstructural gray matter damage in stroke-free patients with chronic arterial occlusion.
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Isolated MPFL Reconstruction Stabilizes Patella Despite High Femoral Anteversion
Patients with femoral torsion over 30 degrees and minimal maltracking achieved stability without derotational osteotomy in a 2-year study.
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Polymeric Clips Match Stapler Safety at Lower Cost in Appendectomy
A retrospective study of 692 patients shows polymeric clips are a cost-effective alternative to staplers for appendiceal stump closure.
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Cerebral Oximetry Fails to Improve 2-Year Outcomes in Preterm Infants
A phase 3 trial of 1,601 infants shows no reduction in death or disability when using oximetry to guide early postnatal care.
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Danish Registry Data Show Rising ADHD Medication Use and Sex Convergence
Prevalence tripled among girls between 2010 and 2023, though they continue to initiate treatment two years later than boys.
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Ubiquinol Slows Motor Decline in Multiple System Atrophy Trial
A Phase 2 trial provides the first placebo-controlled evidence of disease modification by targeting mitochondrial dysfunction in MSA.
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Iron Deficiency Drives Dopaminergic Hypersensitivity in Rodent Restless Legs Model
A study in mice links brain iron deficiency to increased GABA release in the striatal-entopeduncular pathway, mimicking opioid withdrawal.
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Pediatric Knife Fatalities Linked to Deprivation and Prior Social Service Contact
A five-year review of 145 deaths in England identifies high rates of pre-hospital mortality and significant psychosocial vulnerabilities.
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Routine Dementia Screening Shows No Benefit or Harm for Family Members
A randomized trial finds cognitive screening in primary care does not impact family quality of life, preparedness, or psychological distress.
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Vision-Enabled GPT Predicts Tube Thoracostomy Need in Spontaneous Pneumothorax
A retrospective study shows a generative model accurately measures apical depth and aligns with emergency department triage decisions.
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Pre-Diagnosis FEV1 Decline Predicts Mortality in Lung Transplant Recipients
A 20-year cohort study shows that the rate of lung function loss before CLAD onset identifies patients at high risk for rapid progression.
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Valproate Linked to Higher Mortality in Patients With Dementia and Epilepsy
A Swedish registry study finds lamotrigine and levetiracetam associated with better survival than valproate or carbamazepine.
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Vascular Comorbidities Double Mortality Risk in Haploidentical Transplants
A machine-learning analysis identifies a vascular penalty and a three-factor tool to optimize donor selection in allogeneic HCT.
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Cryo-EM Maps Molecular Shift Producing Thrombin in Coagulation Cascade
Researchers identify a 20-angstrom reorientation required for the final proteolytic cleavage of prothrombin into active thrombin.
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Endometrial Cancer Mortality Rises as Management Shifts to Molecular Subtyping
Rising incidence in younger women and stark racial disparities in mortality underscore the need for early biopsy and tailored therapy.