The Briefing
Continuous newsroom coverage of clinically relevant evidence — newest first.
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Subliminal Threat Cues Trigger Sustained Social Avoidance in Women
Eye-tracking data reveals that unconscious perception of anger or disgust leads to reduced visual engagement with subsequent happy faces.
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Acetabular Retention in Hip Resurfacing Conversion Shows 10-Year Durability
Retaining the cup during conversion to total hip arthroplasty maintains 100% component survival but carries high infection risks.
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Sutureless Prosthetic Capsular Bag Stabilizes Lenses in Eyes Without Zonular Support
A first-in-human study of 15 patients shows stable refractive outcomes and low complication rates using a trans-scleral fixation device.
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MIGS Reduces Intraocular Pressure 20% to 50% in Angle-Closure Glaucoma
Minimally invasive techniques combined with lens extraction offer a safer alternative to trabeculectomy by targeting specific anatomy.
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Automated MRI Segmentation Establishes Brain Volume Norms for Very Preterm Infants
Sex-stratified reference ranges for 26 brain regions provide a clinical baseline to identify developmental deviations at term-equivalent age.
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Targeted Hepatitis B Birth Vaccination May Increase Neonatal Infections
A simulation of 3.6 million infants suggests replacing universal birth doses with targeted strategies could add 628 neonatal infections.
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Alternating Venetoclax Triplets Extend Survival in Older AML Patients
A phase 2 trial shows a 45% five-year survival rate and high rates of deep molecular remission using an alternating low-intensity regimen.
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Oncology Care Model Linked to Reduced Therapy in Poor-Prognosis Cancer
Medicare's episode-based payment model did not increase treatment volume and significantly lowered spending for patients with late-stage disease.
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Mailed FIT-DNA Increases Colorectal Cancer Screening Rates in Community Health Centers
A pragmatic trial shows mailed FIT-DNA outreach achieves higher screening uptake than standard FIT, though follow-up colonoscopy rates remain low.
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Subthalamic Nucleus Predominantly Facilitates Action in Primate Models
Electrophysiological data show 89 percent of task-related neurons in the subthalamic nucleus promote rather than inhibit motor choices.
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Cytotoxic T Cells Expand in Antibody-Mediated Kidney Transplant Rejection
Clonal T cell expansion occurs in antibody-mediated rejection even without histological evidence of T cell-mediated rejection.
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Lebrikizumab Maintains 48-Week Efficacy in Systemic-Naive and Experienced Atopic Dermatitis
A prospective study of 187 patients shows high response rates, though prior systemic therapy may limit clearance in head and neck lesions.
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Videolaryngoscopy Increases First-Attempt Success for Double-Lumen Tube Intubation
A multicenter trial of 916 patients shows digital visualization improves glottic view and reduces esophageal intubation rates.
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Online Therapist-Assisted Program Reduces Posttraumatic Stress in Injured Children
A randomized trial shows a digital cognitive behavioral intervention lowers symptom scores for six months following pediatric hospitalization.
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Repeat OnabotulinumtoxinA for Masseter Prominence Does Not Alter Mandibular Bone
A 12-month placebo-controlled trial using CT imaging shows no significant bone remodeling after masseter injections for facial contouring.
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Artificial Intelligence Matches Physician Committees in Adjudicating Cardiovascular Trial Endpoints
An automated system shows high agreement with human experts in identifying major adverse cardiovascular events in a large clinical trial.
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Recurrent Renal Cell Carcinoma Downregulates MHC-I After Adjuvant Atezolizumab
Molecular analysis of IMmotion010 samples suggests a shift toward VEGF-targeted therapy when tumors recur after checkpoint inhibition.
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Trabeculectomy Slows Visual Field Loss Better Than Medication in Advanced Glaucoma
A five-year trial shows surgery preserves monocular vision but finds no significant difference in patient-reported quality of life.
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Serum Neurofilament Light Chain Tracks Acute Injury in Refractory Status Epilepticus
Elevated NfL levels distinguish cryptogenic NORSE from other seizure etiologies and correlate with poor functional outcomes at discharge.
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Heterogeneous Trial Endpoints Limit Evidence in Acute Kidney Injury
A review of 251 trials reveals inconsistent outcome definitions and measurements that hinder clinical application of renal research.
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Gastric Bypass Reversal Relieves Symptoms but Carries High Morbidity Risk
A Swedish cohort study shows 86% symptom relief after reversal, though one in four patients faces early severe complications.
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Higher Daily Step Counts Linked to Reduced Bradykinesia and Increased Dyskinesia
Objective wearable data from 80 patients shows a correlation between physical activity and motor symptom trade-offs in Parkinson's disease.
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Menopause Linked to Significant Lung Function Decline Regardless of HIV Status
Postmenopausal women aged 41 to 50 show a mean FEV1 reduction of 310 mL compared to premenopausal peers in a cross-sectional analysis.
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Schizophrenia Subtype Shows Low Striatal Dopamine and Iron Accumulation
A frontotemporal dementia-like phenotype in schizophrenia patients challenges the universal hyperdopaminergic model of the disease.