The Briefing
Continuous newsroom coverage of clinically relevant evidence — newest first.
Earlier
24 stories-
Outpatient Oncology Records Lack Goals-of-Care Documentation for Most Older Adults
A retrospective study of 7,743 patients found that only 43% had documented goals-of-care conversations in their electronic health records.
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Intravenous NAD+ Reduces Post-Resuscitation Lung Injury in Swine Model
Exogenous NAD+ administration improves oxygenation and limits pulmonary edema by inhibiting ferroptosis-mediated cell death.
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Semaglutide Improves Reward-Based Motivation in Patients With Major Depressive Disorder
A randomized trial shows oral semaglutide reduces the perceived cost of physical effort in patients with depression and elevated BMI.
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Interdisciplinary Whole Health Teams Improve Chronic Pain Function Over Standard Care
A randomized trial of 764 veterans shows that value-aligned team care reduces pain interference more than group therapy or usual care.
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Spectral CT Reconstructions Improve Acute Bowel Ischemia Detection
Adding iodine maps and monoenergetic images to portal venous CT increases diagnostic accuracy from 73% to 86% across scanner platforms.
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MRI Index Quantifies Alzheimer’s Pattern to Predict Dementia Onset
A structural brain vulnerability index identifies early neurodegeneration and predicts conversion from mild cognitive impairment.
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VEGFR1 Blockade Reverses Advanced Diabetic Kidney Damage in Mice
Selective inhibition of VEGFR1 regresses histological lesions and improves survival in murine models of progressive renal failure.
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Patellar Resurfacing Shows No Clinical Advantage in Propensity-Matched TKA Analysis
A large-scale study finds equivalent patient-reported outcomes and complication rates whether or not the patella is resurfaced.
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Prenatal Depression Does Not Alter Infant Oral Microbiome at Birth
A cohort study of 324 mother-infant pairs finds no link between maternal affective symptoms and neonatal microbial diversity or composition.
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Lithuanian Liebowitz Social Anxiety Scale Shows High Reliability in Young Adults
A validation study of the self-report version finds strong internal consistency but suggests total scores are most robust for assessment.
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Plasma Tau and MRI Mismatch Identifies Rapid Alzheimer's Decline
Disproportionate brain atrophy relative to plasma ptau217 levels signals a vulnerable phenotype with faster cognitive loss and co-pathology.
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All of Us Program Links 14 Years of Wearable Data to Clinical Records
A massive dataset connects Fitbit metrics from 59,000 participants to genomics and electronic health records for longitudinal research.
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Chronic and Social Needs Linked to High School Absenteeism
A national study finds children with both chronic health conditions and social instability face a 9.4% risk of missing 11 or more school days.
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Mild Acute Kidney Injury Minimally Affects Long-Term Kidney Function Decline
A study of 1,603 patients finds that mild to moderate AKI causes a small permanent drop in GFR without accelerating annual decline.
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Cesium-131 Collagen Tiles Improve Local Control in Recurrent Meningioma
A phase 2 trial shows resection plus brachytherapy achieves 48% local control at five years for aggressive, recurrent meningiomas.
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Helicopter Transport Increases Survival for Specific High-Risk Trauma Phenotypes
Patients with low Glasgow Coma Scale scores and respiratory distress show the greatest benefit from air medical evacuation.
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Age Over 75 Does Not Increase Facelift Complication Risk
A 10-year retrospective study of 541 patients shows no significant rise in major or minor complications for patients aged 76 and older.
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Gut Microbiome Linked to Macrocephaly in NF1 Mouse Model
Sex-specific microbial signatures correlate with brain size and autism-like behaviors in mice with Neurofibromatosis type 1 mutations.
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UK Data Support Immunoglobulin-Free Maintenance After Liver Transplant
A retrospective study of 273 patients shows that long-term immunoglobulin does not reduce hepatitis B recurrence or improve survival.
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Imaging Score Predicts Survival in Node-Negative Esophageal Cancer
A temporal lymph node stratification score identifies high-risk patients who may benefit from adjuvant therapy after neoadjuvant treatment.
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Low CSF Amyloid-Beta Predicts Intracranial Hemorrhage in CAA Patients
Low levels of amyloid-beta 40 and 42 in cerebrospinal fluid are associated with a sevenfold increase in future symptomatic bleeding risk.
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PD-1 Inhibitors Improve Survival in First-Line NK/T-Cell Lymphoma Treatment
Adding PD-1 inhibitors to asparaginase-based therapy reduces mortality risk by 45 percent in patients with high-risk extranodal disease.
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Ultrasound-Derived Fat Fraction Accurately Grades Steatosis in Chronic Liver Disease
A multicenter study shows ultrasound-derived fat fraction provides high diagnostic accuracy across diverse etiologies and fibrosis stages.
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Targeted sFlt-1 Apheresis Safely Extends Pregnancy in Very Preterm Preeclampsia
A pilot trial shows selective removal of sFlt-1 reduces maternal blood pressure and delays delivery by a median of 10 days.