The Briefing
Continuous newsroom coverage of clinically relevant evidence — newest first.
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US Vitiligo Patients Experience Brief Treatment Durations and High Untreated Rates
A retrospective cohort study of 24,949 patients reveals significant gaps in long-term management and frequent use of short-term therapies.
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Elective Microaxial Flow Pump Does Not Improve High-Risk PCI Outcomes
A randomized trial finds no clinical benefit and a potential mortality signal with routine mechanical unloading during complex revascularization.
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Microaxial Flow Pump Fails to Improve Outcomes in High-Risk PCI
A randomized trial of 300 patients shows elective left ventricular unloading does not reduce major adverse events at 12 months.
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Critical Illness Linked to Significant Income Loss and Unemployment
A nationwide cohort study of 582,341 survivors reveals that over 10% face catastrophic financial decline despite universal coverage.
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Deep Learning Automates PET RANO Criteria Extraction in Glioma Imaging
An externally validated model achieves high agreement with experts in quantifying metabolic tumor volume and tumor-to-background ratios.
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Type 2 Diabetes Linked to Reduced Effort-Based Motivation Unchanged by Semaglutide
A computational study finds metabolic dysfunction drives a cognitive shift toward energy conservation regardless of GLP-1 agonist use.
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Integrated Genetics and MRD Guide Transplant in Ph-Negative ALL
A prospective study shows that combining genetic risk with early molecular response identifies adults who can safely avoid transplantation.
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Abrocitinib Shows Faster Itch Relief Than Dupilumab in Atopic Dermatitis
A post hoc analysis of JADE trials finds oral JAK1 inhibition reaches an itch-free state sooner, correlating with better sleep and quality of life.
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Pure Autonomic Failure Carries 5% Annual Risk of Central Phenoconversion
A meta-analysis identifies hyposmia and sleep disturbances as key predictors of progression to Parkinson disease or multiple system atrophy.
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Management Consultants Show No Benefit for Hospital Finances or Patient Outcomes
A study of 306 nonprofit hospitals found that $7.8 billion in consulting fees did not improve margins, operations, or clinical quality.
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Paramedic Decisions to Withhold Trauma Resuscitation Match Autopsy Findings
A retrospective review of 90 traumatic cardiac arrest cases shows high diagnostic specificity in field assessments of non-survivable injury.
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Microglial Activation Disrupts Hippocampal Memory Consolidation in Aged Mice After Surgery
Surgical stress triggers neuroinflammation that inhibits CA3 to CA1 signaling, reducing sharp-wave ripples essential for memory.
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Heartbeat Evoked Potential Lacks Consistency for Clinical Use
A meta-analysis finds that methodological variability prevents using this neural marker of interoception as a reliable diagnostic tool.
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Veterans Hospitalized for Alcohol Use Disorder Often Miss Medication Initiation Opportunities
A study of 29,041 hospitalizations found that only 30.8% of veterans received medications like naltrexone during or shortly after discharge.
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Automated Software Matches Clinician Accuracy in Peri-operative Echocardiography
A multicenter study shows high agreement between AI-driven analysis and expert measurements for ejection fraction and valvular disease.
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Survival Improves for Leukemia Patients Requiring Mechanical Ventilation in the ICU
An individual participant data meta-analysis of 2003 patients shows declining mortality for ventilated adults with acute leukemia.
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PREVENT and SCORE2 Equations Accurately Predict Global Cardiovascular Risk
A validation study of 6.4 million people confirms these risk models perform well across North America, Europe, and Asia.
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Hippocampal Ripples Coordinate Cortical Planning Sequences in Epilepsy Patients
High-resolution intracranial recordings show that hippocampal ripples and neural replay drive the assembly of complex cognitive solutions.
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Psychotherapy Shows Large, Durable Effects in Treatment-Resistant Depression
A reanalysis of trial data suggests clinical gains stem from simultaneous psychological shifts rather than sequential changes in defense.
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Lifestyle and Psychological Factors Predict Pandemic-Era Depression in Older Adults
A longitudinal study identifies sleep disturbances and reduced physical activity as key drivers of increased depressive symptoms.
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Stable Social Media Addiction Symptoms Link to Adolescent Anxiety and Depression
Longitudinal network analysis identifies tolerance and conflict as core drivers of digital dependency and comorbid internalizing disorders.
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US Neurology Wait Times Average 50 Days Following Primary Care Referral
A retrospective analysis of 114,034 patients identifies significant delays for multiple sclerosis and regional disparities in access.
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Photon-Counting CT Shows Higher Spatial Resolution for Lung Nodules in Phantom Study
New data suggest photon-counting technology maintains noise stability and resolution better than energy-integrating systems at low doses.
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24-Hour Blood Pressure Variability Linked to Cognitive Decline and Brain Aging
Fluctuations in ambulatory blood pressure correlate with impaired executive function and blood-brain barrier leakage in older adults.