The Briefing
Continuous newsroom coverage of clinically relevant evidence — newest first.
LEAD STORY
Tezepelumab Reduces Exacerbations, Improves Lung Function in Diverse Severe Asthma Cohort
A real-world phase 4 study shows tezepelumab's effectiveness and safety across various severe asthma phenotypes and underrepresented patient groups.
Top stories
Yesterday
13 stories-
Younger Brain Age Buffers Cognitive Impact of Tau Pathology
Structural brain integrity, but not education level, modifies the link between p-tau217 and cognitive performance in older adults.
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4-Hydroxybenzoic Acid Restores Endogenous Coenzyme Q10 in COQ2-Deficient Patient
A first-in-human trial shows 4-HBA bypasses biosynthetic blocks to improve neurological and renal outcomes in primary CoQ10 deficiency.
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POGO Score Shows Limited Diagnostic Value in Pediatric Videolaryngoscopy
A study of 904 pediatric intubations found the POGO score performed poorly in classifying difficult airways and predicting adverse events.
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Astegolimab Reduces COPD Exacerbations in Broad Patient Population
A pooled analysis of two trials shows astegolimab significantly lowers moderate/severe exacerbation rates in patients with frequent COPD…
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Semantic-Metacognitive Therapy Improves Naming in Semantic Variant PPA
A single-case experimental study shows specific speech therapy can improve naming performance in individuals with semantic variant primary…
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Abortion Bans Linked to Shifts in Spontaneous Abortion Management
A study of commercially insured individuals finds state-level abortion bans are associated with increased expectant management and misoprostol-only…
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POD1 Prolactin Levels Predict Long-Term Outcomes After Prolactinoma Resection
Postoperative day 1 prolactin levels help stratify risk for hyperprolactinemia rebound and recurrence, especially with prior dopamine agonist use.
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Deep Learning Model Predicts Lung Cancer Risk from Single CT Scan in Asian Cohort
Sybil, an AI model, shows robust performance in predicting future lung cancer risk, including in never-smokers, using low-dose CT.
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Global Psychiatry Congress Reveals Gender, Age, Geographic Representation Patterns
Analysis of the 25th World Congress of Psychiatry highlights attendee demographics and presenter contributions by gender and country income.
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Acetate Attenuates Microglial Inflammation in Traumatic Brain Injury Model, Not Sepsis
Physiological doses of the gut metabolite acetate reduced inflammatory markers in an in vitro TBI model, but not in a sepsis model.
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Platelet mTOR Pathway Drives Neuropathogenesis in Cerebral Malaria
A new study identifies the mechanistic target of rapamycin (mTOR) in platelets as a key mediator of brain injury in experimental cerebral malaria.
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Autonomic Burden Linked to Cognitive Fluctuations in Lewy Body Dementia
A longitudinal study finds autonomic symptom severity correlates with neuropsychiatric burden and reduced caregiver quality of life.
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Anterior Temporal Atrophy Precedes Semantic Dementia Symptoms by Five Years
Large-scale MRI analysis identifies a prolonged prodromal phase and quantifies the prevalence of incidental anterior temporal lobe loss.
This week
7 stories-
Amateur Soccer Heading Linked to Acute Elevations in Neural Damage Biomarkers
A prospective study found that heading in amateur soccer acutely increases blood levels of p-tau217 and S100B, with dose-response relationships.
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Four Clinical Trajectories Identify Distinct Outcomes in Acute Respiratory Failure
A multi-cohort analysis reveals predictable 14-day courses for patients with persistent acute hypoxemic respiratory failure.
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Cervical Spinal Cord Injury Linked to Higher Depression Risk Than Lower-Level Injuries
A nationwide cohort study reveals patients with cervical SCI face a significantly elevated risk of depression compared to those with thoracic/lumbar.
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Exome Sequencing Identifies Genetic Links in Persistent Tachypnea of Infancy
Comprehensive genetic testing reveals that persistent tachypnea of infancy often associates with underlying neurodevelopmental conditions.
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Real-World Data Predicts Long-Term Poor Outcomes in Clinical High-Risk Psychosis
A new model identifies individuals at clinical high risk for psychosis who face diverse long-term adverse events, including hospitalization and suicid
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MEG Reveals Specific Brain and Autonomic Changes in PTSD Affective Processing
Electrophysiological and heart rhythm markers identify altered affective processing in service members with post-traumatic stress disorder.
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CircPCMTD1 Peptide Regulates DNA Damage Response in BCR/ABL1-Positive Leukemias
A newly characterized circular RNA and its peptide product modulate genotoxic stress tolerance, offering a potential therapeutic target.