The Briefing · Emergency & Critical Care
Continuous newsroom coverage of evidence in Emergency & Critical Care — newest first.
LEAD STORY
Tezepelumab Reduces Exacerbations, Improves Lung Function in Diverse Severe Asthma Cohort
A real-world phase 4 study shows tezepelumab's effectiveness and safety across various severe asthma phenotypes and underrepresented patient groups.
Top stories
Yesterday
4 stories-
Astegolimab Reduces COPD Exacerbations in Broad Patient Population
A pooled analysis of two trials shows astegolimab significantly lowers moderate/severe exacerbation rates in patients with frequent COPD…
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Abortion Bans Linked to Shifts in Spontaneous Abortion Management
A study of commercially insured individuals finds state-level abortion bans are associated with increased expectant management and misoprostol-only…
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Acetate Attenuates Microglial Inflammation in Traumatic Brain Injury Model, Not Sepsis
Physiological doses of the gut metabolite acetate reduced inflammatory markers in an in vitro TBI model, but not in a sepsis model.
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Platelet mTOR Pathway Drives Neuropathogenesis in Cerebral Malaria
A new study identifies the mechanistic target of rapamycin (mTOR) in platelets as a key mediator of brain injury in experimental cerebral malaria.
This week
16 stories-
Four Clinical Trajectories Identify Distinct Outcomes in Acute Respiratory Failure
A multi-cohort analysis reveals predictable 14-day courses for patients with persistent acute hypoxemic respiratory failure.
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Cervical Spinal Cord Injury Linked to Higher Depression Risk Than Lower-Level Injuries
A nationwide cohort study reveals patients with cervical SCI face a significantly elevated risk of depression compared to those with thoracic/lumbar.
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Adenoviral Protein Reactivity Linked to Guillain-Barré Syndrome After COVID-19
Patients with post-infection or post-vaccination GBS show heightened antibody responses to adenoviruses, suggesting a shared trigger.
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Continuous EEG Enhances Detection of Post-Stroke Epilepsy Predictors
A retrospective study shows continuous EEG significantly improves identification of epileptiform activity and prediction of post-stroke epilepsy.
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Nebulized Heparin Linked to Reduced Mortality, More Ventilation-Free Days in Respiratory Failure
A meta-analysis suggests nebulized unfractionated heparin improves survival and ventilation-free days in adults with acute respiratory failure…
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Armchair Positioning Improves Oxygenation in Spontaneously Breathing ICU Patients
A randomized controlled trial found out-of-bed armchair positioning increased PaO2/FiO2 ratios compared to in-bed semi-recumbent positioning.
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CANMAT launches 2024 guideline for Major Depressive Disorder Management
The updated CANMAT guideline extends recommended antidepressant maintenance duration and emphasizes earlier adjunctive strategies for limited.
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ASAM launches Joint Clinical Practice Guideline on Benzodiazepine Tapering
This new guideline emphasizes patient-centered, gradual benzodiazepine tapering, with a strong caution against abrupt discontinuation due.
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LANCETP launches 2025 guideline for Algorithmic Treatment of Schizophrenia
New international guidelines emphasize proactive metabolic health management from treatment initiation and earlier consideration of clozapine.
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Heparin Dosing, ACT Monitoring Not Linked to Improved Outcomes After LEB
A large study suggests routine activated clotting time monitoring during lower extremity bypass may not improve patient outcomes.
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HFpEF Patients Exhibit Higher Respiratory Muscle Oxygen Cost During Submaximal Exercise
A study reveals that individuals with heart failure with preserved ejection fraction expend significantly more oxygen for breathing during exertion.
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Pediatric Burn Length of Stay Lower Than Traditional Benchmarks
A multi-institutional analysis of 1,543 pediatric burn patients updates expected hospital stay per TBSA, identifying key influencing factors.
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Lamotrigine-Topiramate Duotherapy Increases Congenital Malformation Risk Fourfold
A large registry study identifies a significant risk increase for specific antiseizure drug combinations used during the first trimester.
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Most Chronic Cough Patients Do Not Achieve Patient-Defined Control Post-Treatment
A single-center observational study established patient-anchored criteria for cough control, finding only 26% of patients met them.
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Fibrin Binding Explains Reduced Circulating Myosin After Trauma
Direct binding of skeletal muscle myosin to fibrin clots may clarify its role in trauma-induced coagulopathy and observed plasma level changes.
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Digital Decision Aid Boosts STI Testing in ED for Young Adults
A randomized trial shows a smartphone-based tool significantly increases gonorrhea/chlamydia and pharyngeal STI testing rates in emergency department