Serum sRAGE Levels Link Biological Rhythm Stability to Depression Severity

Major depressive disorder remains a leading cause of global disability, driven by a complex interplay of neurotransmitter imbalances, hypothalamic-pituitary-adrenal axis dysregulation, and systemic inflammation [1, 2]. Beyond primary mood symptoms, patients frequently experience profound disruptions in biological rhythms, which are increasingly recognized as central to the disease's progression and persistence [3]. These circadian disturbances often manifest as severe insomnia and altered physiological variability, complicating the clinical management of depressive episodes [4, 5]. While various metabolic pathways and immune signals have been implicated in these systemic shifts, the specific molecular bridges linking rhythm stability to psychiatric health remain poorly defined [6]. A new study now investigates a specific circulating receptor that may clarify the relationship between immune signaling and biological rhythm regulation in clinical populations.